Effect of ketamine on hemodynamics and recovery time of propofol sedation for cataract surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138812223520N2

Enrollment

110

Registered

2011-02-01

Start date

2010-10-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

anesthetic agents. Other and unspecified general anaesthetics

Interventions

Intervention 1: intravenous injection of ketamine 0.25 mg/kg in 2 ml volume. Intervention 2: intravenous injection of normal saline in 2 ml volume.

Treatment - Drugs

Placebo

intravenous injection of ketamine 0.25 mg/kg in 2 ml volume

intravenous injection of normal saline in 2 ml volume

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: - ASA I,II - candidate for cattarct surgery -weight lesser than 150% of normal - Blood pressure lesser than 170/110 -no history of hypersensivity to ketamine , propofol, local anesthetics - no history of psychiatric disease , memory or cognitive disease. Exclusion criteria: - operation time ( begining of surgery till its end) - patient who did not cooperate well and need deeper sedation( higher than Ramsay score 3).

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Mean arterial blood pressure. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: in mmHg by automatic blood pressure monitoring.;Pulse rate. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: pulse oximeter.;O2 saturation. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: pulse oximeter.;Propofol dosage. Timepoint: 2 times( dose to get primary sedation, total dose). Method of measurement: calculation from dose injected.	—

Measure

Time frame

Mean arterial blood pressure. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: in mmHg by automatic blood pressure monitoring.;Pulse rate. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: pulse oximeter.;O2 saturation. Timepoint: before and just after drug or placebo injection and then every 2 minutes until 10 minutes , then every 5 minutes till release from recovery. Method of measurement: pulse oximeter.;Propofol dosage. Timepoint: 2 times( dose to get primary sedation, total dose). Method of measurement: calculation from dose injected.

—

Secondary

Measure	Time frame
Operation time. Timepoint: once. Method of measurement: anesthetist watch.;Side effects. Timepoint: as occurs. Method of measurement: record by medical student(intern).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBijan Yazdi

Arak University of Medical Sciences

yazdi@arakmu.ac.ir , yazdibijan@hotmail.com , biyazdi@yahoo.com+98 861222220035

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026