Condition 1: Alzheimer's disease. Condition 2: Alzheimer's disease. Alzheimer's disease Dementia in Alzheimer's disease
Conditions
Interventions
Intervention 1: In control group no drug was used and only one time carry out TCD. Intervention 2: Donepazil(oral) tab with dose of 5mg/d for 1 month and then 5mg/d every 12 hours for another 1 month.
Treatment - Drugs
In control group no drug was used and only one time carry out TCD
Donepazil(oral) tab with dose of 5mg/d for 1 month and then 5mg/d every 12 hours for another 1 month
Sponsors
Isfahan University of Medical Sciences, Isfahan, Iran
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria : age between 50 and 80 years, and the exclusion criteria : history of stroke, nontreated hypertension, diabetes mellitus, smoking during the past 10 years, hypercholesterolemia and taking AchEI drugs one month prior to the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination. Timepoint: before, 1 month and 2 months after intervention. Method of measurement: with checklist.;Peak systolic flow velocity. Timepoint: before, 1 month and 2 months after intervention. Method of measurement: Transcranial Doppler sonography.;Peak diastolic flow velocity. Timepoint: before, 1 month and 2 months after intervention. Method of measurement: Transcranial Doppler sonography.;Mean flow velocity. Timepoint: before, 1 month and 2 months after intervention. Method of measurement: Transcranial Doppler sonography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Shishegar MD
Isfahan University of Medical Sciences, Isfahan, Iran
Outcome results
None listed