Uteroplcental circulation and complication of pregnancy. Pcos (poly cystic ovary syndrome)
Conditions
Interventions
Intervention 1: Metformine, oral Tab, 2000 mg Daily until delivery. Intervention 2: Aspirin, oral Tab, 80 mg daily until delivery. Intervention 3: no treatment until delivery.
Treatment - Drugs
Treatment - Other
Aspirin, oral Tab, 80 mg daily until delivery
no treatment until delivery
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: PCOS diagnosis before pregnancy was based on the presence of poly cystic ovaries verified by ultrasonography and oligomenorea (length of menstrual cycle more than 35 days or hirsutism, gestational age 5-12 weeks, single live fetus, pregnant women between 18-40years and Exclusion criteria: Inability to follow up
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uteroplcental circulation. Timepoint: At 12th week of gestational age (before intervention) and 8 weeks after intervention. Method of measurement: Uterine Artery Doppler Ultrasound. | — |
Secondary
| Measure | Time frame |
|---|---|
| Preterm labour. Timepoint: After Delivery. Method of measurement: Termination of pregnancy before 37th gestational age.;Preeclampsia. Timepoint: Monthly routine control of pregnancy. Method of measurement: Evaluation of BP and urine protein exam.;Rate of Gestational Diabet. Timepoint: at 24-28 weeks of pregnancy or 12-16 weeks after intervention. Method of measurement: GTT.;Rate of IUGR. Timepoint: After Delivery. Method of measurement: weight below the 10th percentile for gestational age after Delivery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Forozan Milani
Guilan University of Medical Sciences
Outcome results
None listed