Protective effects of taurine against MTX, gentamicin and carbamazepin's toxicity

Study of the protective effects of taurine against drug-induced toxicity in the patients treated by MTX, gentamicin and carbamazepin

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT138812123482N1

Enrollment

Registered

2010-09-09

Start date

2010-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Acute Lymphoblastic Leukemia. Condition 2: Infactious deases treated by gentamicin. Condition 3: Seizure. Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue Other bacterial diseases Other disorders of the nervous system

Interventions

Intervention 1: Control: placebo. Intervention 2: Intervention: taurine 2g/d.

Placebo

Treatment - Drugs

Control: placebo

Intervention: taurine 2g/d

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: taking oral MTX or gentamicin or carbamazepin. Exclusion criteria: drug sensitivity, drug side effects, asthma, smoking, death.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Hemoglobin. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Leukocyte count. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;TNF-a. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Creatinin. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Blood urea nitroge. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Alanine aminotransferase (ALT). Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Aspartate aminotransferase (AST),. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Myeloperoxidase (MPO) activity. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Malondialdehyde (MDA),. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Glutathione (GSH). Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Hematocrit. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Platelet. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Taurine. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Hearing power. Timepoint: 3 times (basic, after discharge, 6 month later). Method of measurement: odiometry.;Liver function tests. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.	—

Measure

Time frame

Hemoglobin. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Leukocyte count. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;TNF-a. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Creatinin. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Blood urea nitroge. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Alanine aminotransferase (ALT). Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Aspartate aminotransferase (AST),. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Myeloperoxidase (MPO) activity. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Malondialdehyde (MDA),. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Glutathione (GSH). Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Hematocrit. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Platelet. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Taurine. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.;Hearing power. Timepoint: 3 times (basic, after discharge, 6 month later). Method of measurement: odiometry.;Liver function tests. Timepoint: 6 blood samples , every 2 months. Method of measurement: biochemical methods.

—

Secondary

Measure	Time frame
Drug side effects. Timepoint: every 2 months. Method of measurement: taking history & physical examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Mohammadreza Ghandforoush-Sattari

Tabriz university of medical sciences, Pharmacy school

mrgsuk@yahoo.com+98 41 1337 2252

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026