Effect of intravenous Propofol on post-dural puncture headache

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT138812083437N1

Enrollment

Registered

2010-06-18

Start date

2010-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postdural puncture headache. Other reaction to spinal and lumbar puncture

Interventions

Intervention 1: acetaminophen (500 mg oral every 4 hour for 24 hours). Intervention 2: propofol (1 mg/kg/h IV infusion for 30 minutes every 6 h till 24 hour).

Treatment - Drugs

propofol (1 mg/kg/h IV infusion for 30 minutes every 6 h till 24 hour)

acetaminophen (500 mg oral every 4 hour for 24 hours)

Eligibility

Sex/Gender

All

Age

14 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: suffering from post-dural puncture headache, ASA class 1 and 2, not received intravenous therapy except fluid for their current headache, headache started within last 48 hours Exclusion criteria: Patients with ASA classes other than 1 and 2, receiving intravenous treatment, drug addiction

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Every 5 minutes untill 24 hours. Method of measurement: VAS.	—

Secondary

Measure	Time frame
Opioid need. Timepoint: Every 5 minutes untill 24 hours. Method of measurement: mg of pethidine needed to reduce paine to less than 3 (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactHedayatollah Elyassi

Anesthesiology Research Center

a.r.c@sbmu.ac.ir+98 21 2243 2572

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026