Persons encountering health services for specific procedures and health care. Persons encountering health services for specific procedures and health care
Conditions
Interventions
Intervention 1: administration of magnesium sulphate once 30mg/kg IV before induction of Anesthesia. Intervention 2: administration of normal saline once 30mg/kg IV before induction of Anesthesia.
Prevention
Placebo
administration of magnesium sulphate once 30mg/kg IV before induction of Anesthesia
administration of normal saline once 30mg/kg IV before induction of Anesthesia
Sponsors
Vice Chancellor for Research of Shiraz University of Medical Science,Anesthesia department
Eligibility
Sex/Gender
All
Age
18 Years to 38 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 180 patients (ASA I) healthy adult, (18 to 38years old, both man and woman) that were scheduled for elective non ocular surgery (ENT and ambulatory surgery that needed tracheal intubation), were selected. exclusion criteria: The patients with specific major hepatic, renal and cardio-vascular disease as well as those known to have allergic reaction to magnesium sulphate or other drugs on basis of the history of patients, and hypermagnesemia, hypocalcemia on the basis on lab data, anuria, heart block (ECG), pregnancy, any degree of renal insufficiency, digitalised patients, positive history of glaucoma, or intra ocular hypertension, and patients who refused to participate in this study, were excluded.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Iop (Intra ocular pressure). Timepoint: In 4 stage (T1:Before induction of anesthesia ,T2 :Just before intubation , T3:1 minute after intubation ,T4:5 minute after intubation. Method of measurement: TONOPEN Instrument. | — |
Secondary
| Measure | Time frame |
|---|---|
| Systolic BP. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring.;Diastolic BP. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring.;Mean Arterial Pressure. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: NIBP monitoring.;Heart Rate. Timepoint: 4 stages ; T1 :Before Induction of anesthesia , T2 : just before intubation ,T3 : 1 minute after intubation, T4 :5 minute after intubation. Method of measurement: EKG monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Sina Ghaffari pour
Shiraz Universityof Medical Science
Outcome results
None listed