The effect of primrose and vitex agnus on mastalgia

The effect of evening primrose and vitex agnus on cyclic mastalgia

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138811283227N2

Enrollment

210

Registered

2011-05-10

Start date

2011-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mastalgia. Mastodynia

Interventions

Intervention 1: Intervention group1: Evening Primrose Oil capsules, Cap 500mg, oral-TDS for 2 months (mensturation cycle). Intervention 2: Control group: Vit E capsules, Cap 400 IU, Oral daily for 2

Treatment - Drugs

Intervention group1: Evening Primrose Oil capsules, Cap 500mg, oral-TDS for 2 months (mensturation cycle)

Control group: Vit E capsules, Cap 400 IU, Oral daily for 2 months (mensturation cycle)

Intervention group2: Vitex, Tab 40mg, ora daily after mea for 2 months (mensturation cycle)

Eligibility

Sex/Gender

Female

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 184, pain duration >5 days Exclude criteria: Pregnancy, lactation, patient with psychological and somatic disease, fat ladies (BMI>30), history of breast cancer, hormone therapy since3 months , use of sedative medications, use of Dopamine’s Antagonists, menopause and use of oral contraceptives

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Monthly. Method of measurement: kardif chart - 10 numerical pain scale.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSalehi Ashraf

Arak University of Medical Sciences

salehi.a@arakmu.ac.ir; najm54@yahoo.com+98 86 5222 7550

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026