Comparison the effect of pretreatment with lbuprofen, Indomethacin, and placebo on postoperative pain of mandibular molars with irreversible pulpitis.

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT138811082016N3

Enrollment

150

Registered

2010-02-20

Start date

2009-05-18

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain. Diseases of pulp and periapical tissues

Interventions

Intervention 1: Ibuprofen, 1 capsule of 600 mg, 1 hour before injection of the local anesthetic. Intervention 2: Indomethacin, 1 capsule of 75 mg,1 hour before the local anesthetic injection)1 hour be

Treatment - Drugs

Placebo

Ibuprofen, 1 capsule of 600 mg, 1 hour before injection of the local anesthetic

Indomethacin, 1 capsule of 75 mg,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic

Placebo: 1 capsule contain 500 mg lactos mono hydrate,1 hour before the local anesthetic injection)1 hour before injection of the local anesthetic

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age more than 18 years, no contraindications to taking either Ibuprofen or Indomethacin (history of any allergic reaction to aspirin, NSAIDS, or Lidocaine with Epinephrine, nasal polyp, history of peptic ulcers or GI bleeding, pregnancy and lactation, renal or hepatic disease), no history of GI disorders or ulcer, having no serious systemic disease. Exclusion criteria: no response to cold test, having sensitivity to percussion and palpation, having radiographic changes such as PDL widening, lack of vital pulp in coronal pulp chamber access cavity preparation, the teeth with large restoration, teeth with evidence of crack in their crown, presence of periapical radiolucency, internal resorption or calcification, and also taking narcotic drugs or analgesic drugs in recent 12 hours before treatment.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: 6, 12, 24, and 48 hours after the procedure. Method of measurement: Using Heft-Parker -Visual Analogue Scale (VAS).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNozar Nakhaee

Kerman University of Medical Sciences

nakhaeen@yahoo.com+98 34 1226 3815

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026