rhinosinusitis. Bacterial, viral and other infectious agents
Conditions
Interventions
Intervention 1: Intervention group: drop bottles including fluconazole 2%. is used 2 times per day (4 drops) for 2 months, also beclomethasone nasal spray is used 2 times per day (2 puffs) for 2 month
Treatment - Drugs
Placebo
Intervention group: drop bottles including fluconazole 2%. is used 2 times per day (4 drops) for 2 months, also beclomethasone nasal spray is used 2 times per day (2 puffs) for 2 months.
Control group: drop bottles with the appearance identical to intervention group, includes normal saline which is used 2 times per day, 4 drops, for 2 months. Also beclomethasone nasal spray is used 2
Sponsors
Hamedan University of Medical Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: the patients with diagnosis of chronic rhinosinusitis according to American Academy of Otolaryngology which have no response to medical therapy; Exclusion criteria: known sensitivity to fluconazole; pregnancy and breast feeding women; immune compromised patients; patients with acute complication of CRS; superimposition of ARS(fever, acute pain, pressure on face); antibiotic use in recent 7 days ; age below 18 years; systemic antifungal use in recent 7 days and systemic steroid use in recent 30 days
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Snot-20. Timepoint: 2 months. Method of measurement: Check list.;CT score. Timepoint: 2 months. Method of measurement: Check list. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effect. Timepoint: 2 months. Method of measurement: Check list. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFarnaz Hashemian
Hamedan University of Medical Science
Outcome results
None listed