Recurrent aphthous stomatitis. Recurrent oral aphthae
Conditions
Interventions
Intervention 1: Placebo. Intervention 2: Rosa damascena extract 20%, 4 times per day.
Placebo
Treatment - Drugs
Rosa damascena extract 20%, 4 times per day
Sponsors
Vice Chancellor for Research, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: The presence of at least one aphthous ulcer measuring no more than 10 mm in diameter (formation no more than 48h), had no underlying systemic or immunologic disease such as rheumatoid arthritis and behcet syndrome. Patients were excluded if they had used NSAIDs, corticosteroids or other immunoregulatory agents within 1 month prior to the study or were less than 18 years of age.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Pain. Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: the Perceived Pain Rating Scale as introduced by Barker et al, 1991.;Change in Ulcer Size (mm2). Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: Ulcer size is measured by one examiner with the use of a calibrated dental probe with millimeter markings.;Change in number of Apthae. Timepoint: on day 0 (baseline), days 4, 7, 11 and 14. Method of measurement: Only ulcers which would come into contact with the rinse (i.e. in the oral cavity) will be considered. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactKeyvan Sohrabi
Mashahd University of Medical Sciences
Outcome results
None listed