Prophylactic effect of clofibrate on prevention of jaundice in very low birth weight twin pregnancy neonates

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138811061162N15

Enrollment

Registered

2011-01-26

Start date

2010-09-25

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Very low birth weight hyperbilirubinemia. Other low birth weight

Interventions

Intervention 1: Intervention group: 100 mg of clofibrate. Intervention 2: Control group: sterile water.

Prevention

Placebo

Intervention group: 100 mg of clofibrate

Control group: sterile water

Eligibility

Sex/Gender

All

Age

1 Years to 2 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: twin pregnancy with same gender very low birth weight neonates who are admitted to NICU of Emamreza Hospital. These neonates are healthy, with birth weight equal or less than 1500 grams. Exclusion criteria: Babies with hemolysis, excessive external bleeding, G6PD, sepsis, infection, severe respiratory disease need to ventilation, congenital anomalies and metabolic diseases are excluded

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum bilirubin. Timepoint: befor intervention,24,48,72 and 96 hours after intervention. Method of measurement: measurement of serum bilirubin (diazo method).	—

Secondary

Measure	Time frame
Jaundice. Timepoint: before intervention,24,48,72 and 96 hours after intervention. Method of measurement: observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Ashraf Mohammadzadeh

Neonatal Research Center

mohamadzadeha@mums.ac.ir+98 51 1852 1121

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026