Type 2 diabetes. non-Insulin-dependent diabetes mellitus
Conditions
Interventions
Intervention 1: Control group: plasebo. Intervention 2: Interventinal group: 5mg/day of oral folic acid.
Placebo
Treatment - Drugs
Interventinal group: 5mg/day of oral folic acid
Sponsors
Tabriz university of medical sciences & Nutrition research committee
Eligibility
Sex/Gender
Male
Age
36 Years to 78 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: -having the type 2 diabetes -voluntary consent for participation in the study -use of metformin at least 1500mg/day for >6month. Exclusion criteria: -use of multivitamin-mineral supplements at least 6month before the study -smoking, alcohol abuse -treatment with insulin -having the hepatic, renal failure, cardiovascular, celiac, gastrointestinal, rheumatic, endocrine, thyroid disorders -leukemia -abnormalities in the enzymes that metabolize the hemocysteine –use of corticosteroids, anticonvulsants, isoniazid
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement of antioxidant indices. Timepoint: 8weeks. Method of measurement: Assessments of changes in MDA and TAC.;FBS, insulin resistance, HbA1C, creatinine, lipid profiles. Timepoint: 8weeks. Method of measurement: laboratory.;Serum hemocysteine, folic acid and B12. Timepoint: 8weeks. Method of measurement: laboratory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure. Timepoint: 8weeks after the supplementation. Method of measurement: Sphygmometer.;Body Mass Index. Timepoint: 8 weeks after the supplementation. Method of measurement: Weight(Kg)/height(m2). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactBahram Pourghassem
Health and Nutrition Faculty, Tabriz university of medical sciences
Outcome results
None listed