The effect of vitamin E and zinc supplementation on serum levels of vitamin E, zinc, and antioxidants in beta thalassemia major patients

To study the joint and separate effects of vitamin E and zinc supplementation on serum levels of vitamin E, zinc, and antioxidants in beta thalassemia major patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT138811033139N1

Enrollment

120

Registered

2010-04-24

Start date

2008-10-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Beta Thalassemia major. Cooley's anaemia, Severe beta thalassaemia

Interventions

Intervention 1: cotrol group which did not recieve any supplements. Intervention 2: Zinc sulfate, 220mg daily, orally for three months. Intervention 3: Vitamin E, 400mg daily, orally for three months.

Treatment - Drugs

cotrol group which did not recieve any supplements

Zinc sulfate, 220mg daily, orally for three months

Vitamin E, 400mg daily, orally for three months

Vitamin E, 400mg daily and Zinc sulfate, 220mg daily, orally for three months

Eligibility

Sex/Gender

All

Age

18 Years to 43 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: history of continuous treatment with blood transfusion and desferal as a chellator agent. Exclusion criteria: history of diabetes mellitus, smoking, hepatitis B and C and consumption of any supplements at least three month prior to the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum level of vitamin E. Timepoint: 3 months. Method of measurement: Enzymatic analysis.;Serum level of zinc. Timepoint: 3 months. Method of measurement: enzymatic analysis.;Glutathion peroxidase activity. Timepoint: 3 months. Method of measurement: enzymatic analysis.;Body mass index. Timepoint: 3 months. Method of measurement: Dividing weight (kg) by the second power of height(m).	—

Secondary

Measure	Time frame
Appetite. Timepoint: 3 months. Method of measurement: Questionnaire.;Wellbeing. Timepoint: 3 months. Method of measurement: questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Maryam Rafraf

Nutrition Research Center of Tabriz University of Medical Scienes

rafrafm@tbzmed.ac.ir+98 41 1335 2292

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026