Endothelial Dysfunction in Diabetes Mellitus

Effect of Folic Acid on the Endothelial Dysfunction in Children with Diabetes Type 1

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT138811033138N1

Enrollment

Registered

2010-05-23

Start date

2009-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Melitus Type 1. Insulin-dependent diabetes mellitus

Interventions

Intervention 1: Folic acid, 5mg/day, two perod of 2 months, cross over. Intervention 2: Placebo, 2 period of 2 months, cross over.

Treatment - Drugs

Placebo

Folic acid, 5mg/day, two perod of 2 months, cross over

Placebo, 2 period of 2 months, cross over

Eligibility

Sex/Gender

All

Age

5 Years to 20 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria:1) Children with diabetes type 1 with at least 1 yr duration. 2) Age >5 yr and < 20 yr. 3) No other systemic diseases. 4) No drug use other than insulin. 5) No hypoglycemia or ketosis during past 48 hr. 6) No smoking. 7) No pregnancy. Exclusion criteria: Uncooperae patient

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Endothelial dysfunction. Timepoint: 0, 8, 10, 18 weeks. Method of measurement: ICAM, VCAM, vwf.	—

Secondary

Measure	Time frame
Lipid profile. Timepoint: 0, 8, 10, 18 weeks. Method of measurement: Trigliceride, cholesterol, HDL-c, LDL-c.;Microalbuminuria. Timepoint: 0, 8, 10, 18 weeks. Method of measurement: Urine microalbumin and creatinine.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Hassan Moaddab,MD

Isfahan University of Medical Sciencesisfahan

moadab@med.mui.ac.ir+98 31 1223 1263

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026