major depressive disorder. recurrent depressive disorder
Conditions
Interventions
Intervention 1: ketamine (0.3mg/kg) plus Atropine 0.5 mg (study) for induction of anesthesia before injection of Propofol. Intervention 2: Saline plus Atropine 0.5 mg for induction of anesthesia befor
Treatment - Drugs
Placebo
ketamine (0.3mg/kg) plus Atropine 0.5 mg (study) for induction of anesthesia before injection of Propofol
Sponsors
Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: diagnosis by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (American Psychiatric Association, 2000), of major depressive disorder, age between 18 to 40 years old, Baseline Hamilton Depression Rating Scale (HAM-D) (17-item) score of at least 13, IQ>70 Exclusion criteria: drug or alcohol dependence, any contraindication of ECT, depressive disorder with psychotic features, history of epilepsy, ASA class >2, history of cognitive disorder
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: baseline and one day after the third and the last ECT session and 2 weeks after the last session. Method of measurement: Hamiltion Depression Rating Scale 17-Item. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Farzin Rezaei
Kurdistan University of Medical Sciences
Outcome results
None listed