Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on postoperative nausea and vomiting in diagnostic gynecologic laparascopy

Comparison the effects of fentanyl, sufentanil and alfentanil as premedication on postoperative nausea and vomiting in diagnostic gynecologic laparascopy in hundred eighty patients (ASA I and II), aged 18-35 year

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138810293104N1

Enrollment

180

Registered

2012-08-24

Start date

2010-03-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gynecologic. N80-N98

Interventions

Intervention 1: Midazolam 1mg and alfentanil 2cc (1000µg). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isofl

was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of every three group was performed using thiope

Treatment - Drugs

Midazolam 1mg and alfentanil 2cc (1000µg). Induction of every three group was performed using thiopental (5mg/kg) and succynyl choline (1.5mg/kg), anesthesia was maintained using isoflurane 1.2% gas a

Midazolam 1mg and fentanil 2cc (100µg)

Midazolam 1mg and sufentanil 2cc (10µg) was administered to the patients two minutes before I.V. induction of anesthesia to the patient (each 1cc of the three drugs has equal power). Induction of ever

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Patients were selected from those who referred to afzalipoor hospital of Kerman for diagnostic GLS and were aged 18-35 with ASA I or II. Exclusion criteria: diabetes mellitus; addiction to drugs; history of nausea or vomiting and or using drugs with known anti-emetic properties (like metformin, clomifen, medroxy progestron, bromocriptin) 24 hours before the surgery; smoking; motion disease history; previous experience of PONV; surgical duration more than 45 minutes; usage of opioids after surgery in recovery period and weight more than 70kg. After signing informed consent by all the patients, 180 subjects were enrolled in the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Vomitting. Timepoint: 0-24, 0-2, 2-24(0-24 hours after surgury). Method of measurement: Observation.;Nausea. Timepoint: 0-24, 0-2, 2-24(0-24 hours after surgury). Method of measurement: Observation.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Shabani

Kerman Neuroscience Research Center

shabanimoh@yahoo.com+98 34 1226 4198

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026