Evaluation the effect o f Remifentanil on Succinylcholine-indused biochemical changes during anesthesia

Evaluation the effects of combination of Propofol-Remifentanil on Succinylcholine induced post operative fasciculations, myalgia and biochemical changes in lower abdominal surgeries

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138810141766N3

Enrollment

Registered

2010-04-05

Start date

2009-10-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Complication of muscle relaxant drugs (succinylcholine), not elsewhere classified. Other adverse effects, not elsewhere classified

Interventions

Intervention 1: Injection of Remifentanil 1mcg/kg two minutes before the induction of anesthesia. Intervention 2: Injection of 3 ml saline normal 0.9% (placebo) two minutes before the induction of ane

Treatment - Drugs

Placebo

Injection of Remifentanil 1mcg/kg two minutes before the induction of anesthesia

Injection of 3 ml saline normal 0.9% (placebo) two minutes before the induction of anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Scheduled for elective surgery of lower abdomen (such as inguinal hernia, hydrocele and ...), signing informed consent, ASA class of 1 or 2. Exclusion criteria: addiction (opioides, alcohol, or psychological drugs), history of allergic reaction to study drugs, cholinesterase deficiency, hypertension, neuromuscular disease, pregnancy, and using drugs that interact with neuromuscular function.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum potassium level changes. Timepoint: befor induction of anesthesia and 5 minutes after injection of succinylcholine. Method of measurement: Laboratory.;Serum creatine phosphokinase level (CPK) changes. Timepoint: before induction of anesthesia and 24 hours after that. Method of measurement: Laboratory.	—

Secondary

Measure	Time frame
Blood pressure changes. Timepoint: Before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (automated pressure gauge).;Heart rate changes. Timepoint: before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (by automated monitoring).;Postoperative myalgia. Timepoint: In 5 times, 2, 6, 24, 48 and 72 hours after operation. Method of measurement: By a 4-point scale questionnaire.;Duration of fasciculation. Timepoint: after injection of succinylcholine. Method of measurement: Chronometer.	—

Measure

Time frame

Blood pressure changes. Timepoint: Before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (automated pressure gauge).;Heart rate changes. Timepoint: before induction of anesthesia, after induction of anesthesia and after tracheal intubation. Method of measurement: Clinically (by automated monitoring).;Postoperative myalgia. Timepoint: In 5 times, 2, 6, 24, 48 and 72 hours after operation. Method of measurement: By a 4-point scale questionnaire.;Duration of fasciculation. Timepoint: after injection of succinylcholine. Method of measurement: Chronometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactShoaleh Shami

Nursing and Midwifery School, Kurdistan University of Medical Sciences

shami471@yahoo.com+98 87 1666 0733

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026