comparison of Letrozole and Clomiphene in combined regimens with gonadotropins in pregnancy rate in pcos patients with clomiphene resistant polycystic ovarian syndrome.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138810132967N1

Enrollment

120

Registered

2010-02-27

Start date

2007-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Clomiphene resistant polycystic ovarian syndrome. Noninflammatory disorders of female genital tract

Interventions

Intervention 1: Letrozole 5mg (2 tablets) orally from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh

Treatment - Drugs

Letrozole 5mg (2 tablets) orally from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle af

Clomiphene 100mg (2 tablets) from 3-7 days of menstrual cycle in addition to gonadotropine (HMG) ampule 5th to 9th days of menstrual cycle which was continued on tenth or eleventh day of cycle after t

Eligibility

Sex/Gender

Female

Age

20 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Clomiphene resistant polycystic ovarian syndrome, age 20-35 years Exclusion criteria: BMI more than 27, presence of hypothyroidism, hyperprolactinemia, or decreased ovarian reserve, male factor infertility, tubal or uterine factor diagnosed by HSG, peritoneal factor (history of previous surgery)

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Endometrial thickness. Timepoint: Tenth or eleventh day of menstrual cycle. Method of measurement: Transvaginal sonography.;Ovarian response. Timepoint: Tenth or eleventh of menstrual cycle. Method of measurement: Transvaginal sonography.	—

Secondary

Measure	Time frame
Gonadotropin ampule consuption. Timepoint: Tenth or eleventh of menstrual cycle. Method of measurement: Transvaginal sonography.;Pregnancy rate. Timepoint: Two weeks after HCG injection. Method of measurement: pregnancy test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Fatemeh Foroozanfard

Kashan University of Medical Sciences

forozanfar_f@kaums.ac.irfatemehforoozanfard@yahoo.com+98 36 1542 1355

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026