bipolar disorder type one. Bipolar affective disorder
Conditions
Interventions
Intervention 1: Remifentanil (100 µg) plus Atropine 0.5 mg (study) for induction of anesthesia before injection of Propofol. Intervention 2: Saline plus Atropine 0.5 mg for induction of anesthesia bef
Treatment - Drugs
Remifentanil (100 µg) plus Atropine 0.5 mg (study) for induction of anesthesia before injection of Propofol
Sponsors
Kurdistan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Exclusion criteria: (1) a history of ECT during the preceding 6-month period; (2) use of nonbenzodiazepine anticonvulsants (valproate, carbamazepine, lamotrigine, or topiramate), lidocaine, theophylline, or lithium during the last week; (3) a history of rapid-cycling or mixed bipolar illness, schizophrenia, or another psychotic disorder that was not part of the mood disorder; (4) neurological illness or severe medical illness, 5) pregnancy, 6) stroke within the past 3 months, 7) brain surgery 8) severe head trauma, 9) drug or alcohol dependence within the past 2 years. 10)seizure duration more than 90 seconds in each episodes of ECT. Inclusion criteria: 1) diagnosis by Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) (American Psychiatric Association, 2000), of a bipolar I disorder (manic episode) 2) age between 18 to 45 years old 3) The minimal score on Young Mani Rating Scale (YMRS)=20 4) Signed informed consent 5) IQ>70 6) ASA class 1 or 2
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of mania. Timepoint: baseline and one day after the third, the sixth, and the last ECT sessions. Method of measurement: Young Mania Rating Scale (YMRS).;Cognitive status. Timepoint: Mini-Mental State Examination (MMSE). Method of measurement: baseline and one day after the third, the sixth, and the last ECT sessions.;Orientation. Timepoint: once subjects will be removed into the recovery room and will be repeated every 15 minutes. Method of measurement: post –treatment reorientation time test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of seizure. Timepoint: during each session of ECT. Method of measurement: mesurement of duration of seizure. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Farzin Rezaei
Kurdistan University of Medical Sciences
Outcome results
None listed