pancreatitis. Idiopathic acute pancreatitis
Conditions
Interventions
Intervention 1: indomethacin 100 mg anal with sublingual tablet of isosorbide dinitrate 5 mg. Intervention 2: indomethacin 100 mg anal with sublingual placebo of isosorbide dinitrate 5 mg.
Treatment - Drugs
Placebo
indomethacin 100 mg anal with sublingual tablet of isosorbide dinitrate 5 mg
indomethacin 100 mg anal with sublingual placebo of isosorbide dinitrate 5 mg
Sponsors
Digestive disease research center
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Study populations are all patients referred to Shariati hospital who undergo therapeutic or diagnostic ERCP in endoscopy ward. Exclusion criteria: age<18; HX of nitrate use; HX of recent acute pancreatitis (less than one month); HX of chronic pancreatitis; recent (2weeks) peptic ulcer bleeding; HX of glaucoma; ampullary tumor; use of sildenafil; unwilling for consent; allergy to drugs; previous sphincterotomy.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Post ercp pancratitis. Timepoint: 24 hours after ercp. Method of measurement: pain observative scale, serum amylase measurement, hospitalation period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea and vomiting. Timepoint: 24 hours after procedure. Method of measurement: asking from patient.;Fever/chills. Timepoint: 2 and 24 hours after procedure. Method of measurement: check of fever grade with termometer.;Upper GI bleeding. Timepoint: 2 and 24 hours after procedure. Method of measurement: check of vital sighns, hematemesis and melena. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMaryam Farsinejad
Digestive Disease Research Center
Outcome results
None listed