Assessment of effect of Fenugreek seed on the insulin resistancy in the infertile women with polycystic ovarian

Assessment of addetive effect of Fenugreek seed extract on the insulin resistancy in infertile women with polycystic ovarian syndrom

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT138810082924N1

Enrollment

Registered

2010-02-02

Start date

2007-11-26

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Insulin resistance in infertile women with polycystic ovarian syndrome(PCOS). Other disorders of genitourinary tract

Interventions

Intervention 1: Intervention group: hydroalcholic of fenugreek seeds extract capsuls and metformin tablet (Fenugreek capsuls of 500mg twice daily and metformin tablets of 500mg three times a day for 8

Treatment - Drugs

Placebo

Intervention group: hydroalcholic of fenugreek seeds extract capsuls and metformin tablet (Fenugreek capsuls of 500mg twice daily and metformin tablets of 500mg three times a day for 8 weeks)

Control group: placebo capsuls and metformin tablet(Placebo capsuls twice daily and metformin tablets of 500mg three times a day for 8 weeks)

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. female infertility,2. To have two of three criteria for PCOS( oligo/amenorrhea, clinical sign or biochemical hyperandrogenism, PCOS in sonographic view), 3. insulin resistance (FGIR<4.5), 4. FBS<200mg/dl, 5. normal function of liver and kidney(Cr<1.4mg/dl), 6. selected for ovarian stimulation. Exclusion criteria: 1.diabetes mellitus type one, hyperprolactinemia, hypothyroidism, adrenal disorder, abnormal HSG, previous medical disease (septecemia, kidney failure, congestion heart failure, gastrointestinal disorder), confound drugs to the metformin.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Insulin resistance. Timepoint: End of 8 weeks. Method of measurement: Biochemical and hormonal tests.;Fasting blood sugar (FBS). Timepoint: End of 8 weeks. Method of measurement: Biochemical test.;Golucose tolerance test of two hours (GTT). Timepoint: End of 8 weeks. Method of measurement: Biochemical test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Hassanzadeh Bashtian

Mashhad university of medical sciences

bashtian@yahoo.com; M.H.Bashtian@gmail.com+98 51 1867 4826

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026