Respiratoty Distress Syndrome of neonates. Respiratory distress syndrome of newborn
Conditions
Interventions
Intervention 1: cleaning of the endotracheal tube every 6 hours with 2 mililiter of N-acetylsucteine solution. Intervention 2: cleaning of the endotracheal tube every 6 hours with 2 mililiter of norma
Placebo
cleaning of the endotracheal tube every 6 hours with 2 mililiter of N-acetylsucteine solution
cleaning of the endotracheal tube every 6 hours with 2 mililiter of normal saline solution
Sponsors
Vice chancellor for research, Iran University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Neovates > 1200 gram hospitalized in NICU of Rasoul Akram hospital and needed to be intubated and mechanically ventilated based on standard protocols. Exclusion Criteria: Neonates with major anomalies or cyanotic cardiac diseases, neonates who ere intubated at the beginning of their hospitalization, neonates with pneumothorax at the time of hospitalization or intubation, massive hemorrhage, neonates who were extubated before 24 hours or dead before this time
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of first intubation until exchange of endotracheal tube due to mucus plug retention. Timepoint: every 6 hours. Method of measurement: Tube cleaning with drugs in order to make sure that it's open. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of endotracheal tube obstruction and replacement due to mucus plug. Timepoint: every 6 hours. Method of measurement: cleaning of the endotracheak tube to make sure that it's open.;Duration of intubation. Timepoint: every day. Method of measurement: observation.;Events those may be related to the new drug including apnoea and bradycardia, hypotension, pulmonary haemorrhage. Timepoint: every 6 hours. Method of measurement: monitoring of the patient.;Death. Timepoint: every 6 hours. Method of measurement: control of vital signs. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyyed Mohammad Fereshteh Nejad
Iran University of Medical Sciences and Health Servuces
Outcome results
None listed