Massive Ischemic stroke. Stroke
Conditions
Interventions
Intervention 1: Intervention: Noscapine syrup, three doses of 50 mg/day for 5 days. Intervention 2: Control: routine care.
Treatment - Drugs
Intervention: Noscapine syrup, three doses of 50 mg/day for 5 days
Sponsors
Iran university of medical sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: baseline National Institutes of Health Stroke Scale (NIHSS) level of consciousness >2 (no comatosis), motor function of arm and leg, totally >2, and total NIHSS score (excluding distal motor function) >7. Exclusion criteria: Modified Rankin Scale >2 prior to the onset of present stroke, patients whose neurological findings rapidly improve, patients with sepsis, meningitis or subarachnoid hemorrhage, post-seizure patients with a neurological deficit that could not be distinguished from Todd’s phenomenon, known presence or clinical suspicion of an intracranial neoplasm or mass lesion or sequelae to head trauma ,serious medical illnesses or conditions involving organ failure, such as severe congestive heart failure or severely compromised pulmonary, renal or hepatic function, respiratory dependence or unstable vital signs, a preexisting or concomitant medical, neurological or psychiatric disorder that could confound determination of the patient’s level of function or otherwise compromise the study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality. Timepoint: 1 month. Method of measurement: patient' s medical documents. | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug's side effects. Timepoint: daily. Method of measurement: Reports of nurses and physicians. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Mohamad Rezvani
Iran university of medical sciences
Outcome results
None listed