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Effects of antithyroid drug therapy on bone mineral density of young women with endogenous subclinical hyperthyroidism

Effects of antithyroid drug therapy on bone mineral density of young women with endogenous subclinical hyperthyroidism

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT138809012750N1
Enrollment
30
Registered
2010-05-11
Start date
2009-05-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Subclinical hyperthyroidism. Thyrotoxicosis, unspecified Hyperthyroidism NOS

Interventions

Intervention 1: Intervention: Methimazole 5-10 mg/day po until the patient become euthyroid then 2.5-5 mg/day po maintenace dose for 1 year. Intervention 2: Control: Without any intervention for 1 yea
Treatment - Drugs
Intervention: Methimazole 5-10 mg/day po until the patient become euthyroid then 2.5-5 mg/day po maintenace dose for 1 year.
Control: Without any intervention for 1 year

Sponsors

Kurdistan university of medical sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
15 Years to 55 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Young women referred to Kurdistan nuclear medicine center for thyroid evaluation which has suppressed TSH and normal FT4 and FT3 without history of thyroid disorders. Exclusion criteria: Secondary osteoporosis, hypersensitivity to oral anti-thyroid drugs, discontinuation of 1 year follow-up

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Thyroid function. Timepoint: 3-6-12 months after treatment. Method of measurement: TSH, freeT3, freeT4 measurement by IRMA & RIA methods.

Secondary

MeasureTime frame
Bone mineral density. Timepoint: 12 months after treatment or follow-up. Method of measurement: Measuring BMD of lumbar vertebrae(L2-L4) and femoral neck by DXA method.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSiamak Derakhshan M.D

Kurdistan university of medical science

siamak.derakhshan@muk.ac.ir; siamakderakhshan@yahoo.com+98 87 1662 6970

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026