The effect of topical olive leaf extract 2% and topical acyclovir 5% on facial herpes simplex

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138808092652N1

Enrollment

Registered

2010-01-21

Start date

2009-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

herpes simplex facialis. Herpesviral vesicular dermatitis

Interventions

Intervention 1: A thin layer of topical ointment of olive leaf extract 2% were applied 5 times per day for 6 days. Intervention 2: A thin layer of topical cream of Acyclovir 5% were applied 5 times pe

Treatment - Drugs

A thin layer of topical ointment of olive leaf extract 2% were applied 5 times per day for 6 days

A thin layer of topical cream of Acyclovir 5% were applied 5 times per day for 6 days

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Having facial herpes simplex, willingness to participate in the study and sign a written consent Exclusion criteria: Participation in drug therapy including corticosteroids, antiviral drugs and immunosuppressive drugs, immune deficiency, metabolic, chronic, or serious systemic illnesses, simultaneous participation in another research, hypersensitivity to antivirus drugs

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: severity of pain was scaled by Mcgill-Melzak method.;Itching. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: by Mcgill-Melzak method.;Success of treatment. Timepoint: 3 and 6 days after treatment. Method of measurement: percentage of cured patients.;Lesion size. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: Using a disposable folding ruler.;Bleeding. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: Presence of bleeding.;Color change. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: color change comparing to the skin.;Side effects. Timepoint: 3 and 6 days after treatment. Method of measurement: based on patient's complaint.	—

Measure

Time frame

Pain. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: severity of pain was scaled by Mcgill-Melzak method.;Itching. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: by Mcgill-Melzak method.;Success of treatment. Timepoint: 3 and 6 days after treatment. Method of measurement: percentage of cured patients.;Lesion size. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: Using a disposable folding ruler.;Bleeding. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: Presence of bleeding.;Color change. Timepoint: before treatment, 3 and 6 days after treatment. Method of measurement: color change comparing to the skin.;Side effects. Timepoint: 3 and 6 days after treatment. Method of measurement: based on patient's complaint.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactBahram Delfan

Lorestan University of Medical Sciences

delfan.b@lums.ac.ir+98 66 1620 0150

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026