Recommending Zinc Sulfate supplement as a new treatment approach in obese children to improve metabolic profiles (such as LDL, HDL, blood sugar) in plasma

The effect of Zinc Sulfate on Insulin resistance indices, Apo lipoproteins, Oxidative stress and inflammatory factors in obese children

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT138808061434N2

Enrollment

Registered

2009-12-29

Start date

2008-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic Syndrome. Other disorders of lipoprotein metabolism

Interventions

Intervention 1: Placebo capsule once daily for 2 months. Intervention 2: Zinc Sulfate tablet (containing 20 mg Zinc element) once daily for 2 months.

Placebo

Placebo capsule once daily for 2 months

Zinc Sulfate tablet (containing 20 mg Zinc element) once daily for 2 months

Eligibility

Sex/Gender

All

Age

6 Years to 10 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: underwriting consent form by one of parents or legal guardian, simple obesity, pre-pubertal stage, no underlying health disorder Exclusion criteria: Possible drug side effects, no compliance for follow up

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Waist circumference. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Non elastic tape with accuracy of 0.1 cm.;Weight. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: SECA medical scale with the accuracy of o.1 kg.;Height. Timepoint: At the beginning of study. Method of measurement: SECA stadiometer with the accuracy of 0.1 cm.;Blood pressure. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Mercury sphygmomanometer with the accuracy of 1mmHg.;High-density lipoprotein (HDL). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Triglycerides(TG). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Fasting Blood Sugar(FBS). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Glucose Oxidase method.;Zinc level of plasma. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.	—

Measure

Time frame

Waist circumference. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Non elastic tape with accuracy of 0.1 cm.;Weight. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: SECA medical scale with the accuracy of o.1 kg.;Height. Timepoint: At the beginning of study. Method of measurement: SECA stadiometer with the accuracy of 0.1 cm.;Blood pressure. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Mercury sphygmomanometer with the accuracy of 1mmHg.;High-density lipoprotein (HDL). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Triglycerides(TG). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Fasting Blood Sugar(FBS). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Glucose Oxidase method.;Zinc level of plasma. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.

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Secondary

Measure	Time frame
Total cholesterol. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Low Density Lipoprotein(LDL). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Directly.;Fasting Insulin. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.;HOMA-IR. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: calculation.;Hs-CRP. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Immunoturbidimetry.;Leptin. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: serum.;Malonyl dialdehid. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Serum.;APOA. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.;APOB. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.	—

Measure

Time frame

Total cholesterol. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Enzymatic.;Low Density Lipoprotein(LDL). Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Directly.;Fasting Insulin. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.;HOMA-IR. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: calculation.;Hs-CRP. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Immunoturbidimetry.;Leptin. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: serum.;Malonyl dialdehid. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: Serum.;APOA. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.;APOB. Timepoint: At the beginning, 2nd month and 5th month of study. Method of measurement: ELISA.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactRoya Kelishadi

Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences

kelishadi@med.mui.ac.ir+98 31 1337 7881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026