Polycistic overian syndrome. Polycistic overian syndrome
Conditions
Interventions
Intervention 1: Flutamide and/or Metformin. Intervention 2: Hypocaloric dieting. Intervention 3: Placebo.
Treatment - Drugs
Lifestyle
Placebo
Flutamide and/or Metformin
Hypocaloric dieting
Sponsors
Vice Chancellor for Research and Technology, Babol University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Reproductive age (range 18-45 yr), body mass index (BMI) at least 28 kg/m2, and waist circumference at least 88 cm, chronic an ovulation severe oligomorrhea or amenorrhea, hirsutism (Ferriman – Gallwey score 8), total testosterone levels at least 0.72 ng/ml and polycystic ovarian morphology at ultrasound. Exclusion criteria: Use of any medication or a significant modification in body weight within the previous 3 months or dieting, hyperprolactinemia, cushing’s syndrome, late–onset congenital adrenal hyperplasia, thyroid dysfunction, diabetes, cardiovascular, renal or Liver diseases, positive pregnancy test.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anthropometric measurement. Timepoint: monthly. Method of measurement: physical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum Lipid. Timepoint: monthly. Method of measurement: Lab.;Serum glucose. Timepoint: monthly. Method of measurement: lab.;Fasting insulin. Timepoint: 6 months. Method of measurement: lab.;Testosteroe, OHEA, SHBG. Timepoint: 6 months. Method of measurement: lab.;Hirsotism. Timepoint: 6 months. Method of measurement: physical examination. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNargess Gholizadeh Pasha
Fatemehzahra Fertility & reproductive Health Research Center
Outcome results
None listed