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Comparison of the efficacy of two routes of misoprostol administration (sublingual and vaginal) for termination of second trimester pregnancy

Comparison of the efficacy of two routes of misoprostol administration (sublingual and vaginal) for termination of second trimester pregnancy

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138807202576N1
Enrollment
210
Registered
2010-11-28
Start date
2009-06-15
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy, childbirth and the puerperium. -

Interventions

Intervention 1: Vaginal misoprostol 200mg/6h till 10th dose, if there is not response then curretage is done for termination of pregnancy. Intervention 2: Sublingual misoprostol 200mg/6h till 10th do
Treatment - Drugs
Vaginal misoprostol 200mg/6h till 10th dose, if there is not response then curretage is done for termination of pregnancy
Sublingual misoprostol 200mg/6h till 10th dose if there is not response curretage is done for termination of pregnancy

Sponsors

Tehran university of medical university
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
14 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All pregnant women in their second trimester (14-28 weeks) who have been referred to Mirzakoochakkhan hospital for termination of pregnancy; willingness to participate in the study. Exclusion criteria: Allergic reaction to prostaglandin; HTN; Glaucoma; more than twice repeat caesarean section; prolong PPROM; adrenal insufficiency; Parity > 5

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Abortion without surgical intervention. Timepoint: 24 -48hour. Method of measurement: Trans vaginal sonography.

Secondary

MeasureTime frame
There is no residue of pregnancy. Timepoint: 24-48 h. Method of measurement: Trans vaginal sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Davari Tanha

Tehran university of medical sciences-

fdavaritanha@sina.tums.ac.ir+98 21 8831 3955

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026