Acute myocardial infarction. Acute transmural myocardial infarction of anterior wall
Conditions
Interventions
Intervention 1: Cyclosporine 2.5 mg/kg in intervention group (pre thrombolytic). Intervention 2: Normal saline in control group (pre thrombolytic).
Treatment - Drugs
Cyclosporine 2.5 mg/kg in intervention group (pre thrombolytic)
Normal saline in control group (pre thrombolytic)
Sponsors
Research vice-chancellor of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 85 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria : in patients with 18 years of age or older, presence of ischemic chest pain and ST segment elevation of 1 mm or more in at least two contiguous leads of anterior region, who admits in primary six hours of symptoms onset and candidate for thrombolytic therapy Exclusion criteria : cardiac arrest, primary VF, prior MI, uncontrolled HTN, known hypersensitivity to cyclosporine, known renal failure or a serum creatinine level of 120 mol per liter (1.36 mg per deciliter) or more at admission, liver failure, and women who were pregnant or who were of childbearing age and were not using contraception, any disorder that is associated with immunologic dysfunction e.g., cancer, lymphoma, a positive serologic test for the human immunodeficiency virus, or hepatitis
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LVEF. Timepoint: 1st day & predischarge. Method of measurement: echocardiography.;Incidence of Heart Failure. Timepoint: During admission. Method of measurement: Basal pulmonary rales , lasix using, chest XRAY.;Incidence of Arrhythmia. Timepoint: During admission. Method of measurement: ECG monitoring. | — |
Secondary
| Measure | Time frame |
|---|---|
| All cause mortality rate. Timepoint: in hospital & 6 month later. Method of measurement: patient documents & calling. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Mehdi Toluey Khormazard
Tabriz University of Medical Sciences
Outcome results
None listed