The comparison of the therapeutic effect of Desmopresin, Oxybutinin, and Imipramin in the treatment of nocturnal enuresis in children

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138807042503N1

Enrollment

Registered

2010-05-30

Start date

2009-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nucturia. Nonorganic enuresis

Interventions

Intervention 1: Desmopressin, nasal spray, 1-2 puff every night for 6 weeks. Intervention 2: Oxybutinin 5mg, po, at bedtime every night for 6 weeks. Intervention 3: Imipramin, 10-20 mg, po, at bedtime

Treatment - Drugs

Desmopressin, nasal spray, 1-2 puff every night for 6 weeks

Oxybutinin 5mg, po, at bedtime every night for 6 weeks

Imipramin, 10-20 mg, po, at bedtime every night for 6 weeks

Eligibility

Sex/Gender

All

Age

5 Years to 14 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Age 5-14, presence of nocturnal enuresis, patient's and parents consent for treatment and follow up, no underlying diseases, not receiving any medicine for enuresis during 6 months prior to the study, failure to response to the other non pharmacological therapies Exclusion criteria: disagreement of parents or patients for treatment, developing any drugs side effects

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Response rate (discontinuing enuresis). Timepoint: 1, 2, 3, and 4 months after intervention. Method of measurement: observation and interview and collecting data from questionnaires.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Seyfhashemi

Semnan University of Medical Sciences

m-Seyf@sem-ums.ac.ir+98 23 1444 6309

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026