Peptic Ulcer Disease (H. Pylori eradication). Duodenal ulcer
Conditions
Interventions
Intervention 1: Intervention group: Pantoprazole 40mg (BD) for 10 days + Amoxicillin 1g (BD) just during the first 5 days + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) just during the second
Treatment - Drugs
Intervention group: Pantoprazole 40mg (BD) for 10 days + Amoxicillin 1g (BD) just during the first 5 days + Clarithromycin 500mg (BD) and Tinidazole 500mg (BD) just during the second 5 days
Control group: Pantoprazole 40mg (BD) + Amoxicillin 1g (BD) + Bismuth 240mg (BD) for 2 weeks and Furazolidone 200mg (BD) just during the first week
Sponsors
Vice Chancellor For Research, Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: age more than 18 years Exclusion criteria: Previous history of receiving any H.p eradication regimen, Taking H2 blocker, proton pump inhibitor, Bismuth or Antibiotics during the 2 weeks prior to the study, Taking anticoagulants, ketoconazole or corticosteroids, History of gastric or esophageal surgery, Severe cardiovascular, pulmonary or endocrine disease, Renal failure, Hepatic diseases, Malignancies, Alcoholism, G6PD deficiency, Pregnancy or breast feeding
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication. Timepoint: 2 months after the completion of treatment course. Method of measurement: urease breating test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects of drugs. Timepoint: daily recording during and after the treatmen course. Method of measurement: classifying as mild, moderate or severe side effects. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Hafez Tirgar Fakheri
Mazandaran University of Medical Sciences
Outcome results
None listed