Ovarian Hyperstimulation Syndrome. Other obstetric conditions, not elsewhere classified
Conditions
Interventions
Intervention 1: routine treatment for prevention of OHSS. Intervention 2: Methylprednisolone 16mg/daily orally, until 5 weeks plus 1 gm IV injection on retrieval and embryo transfer day.
Treatment - Drugs
routine treatment for prevention of OHSS
Methylprednisolone 16mg/daily orally, until 5 weeks plus 1 gm IV injection on retrieval and embryo transfer day.
Sponsors
Royan Institute
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1.Poly Cystic Ovarian Syndrome patients 2.Indication for IVF/ICSI and Long Protocol ovarian stimulation 3.Age<35 4.Basal FSH=10 5.Normal BMI (20-25) 6.Physical health Exclusion Criteria: 1. Allergy to GnRH analogues, FSH and corticosteroids 2. presence of heart failure, recent myocardial infarction, Hypertension, Diabetes mellitus, epilepsy, glaucoma, hypothyroidism, hepatic failure, osteoporosis, peptic ulceration, psychosis, or severe affective disorders and renal impairment. 3. Using drugs that have interaction with corticosteroids such as Cyclosporine, Phenobarbital, Phenytoin, Rifampin, Ketoconazole, Aspirin and Anticoagulants (All of these drugs shouldn’t be used during recent 2 weeks prior to the study and during corticosteroids consumption)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OHSS occurrence rate. Timepoint: Until 20 days after embryos transfer (ET). Method of measurement: accordance with the Golan 5 grade system. | — |
Secondary
| Measure | Time frame |
|---|---|
| Estradiol concentration. Timepoint: on the day before hCG administration. Method of measurement: laboratory results.;Retrieved and injected oocytes number and quality. Timepoint: oocyte retrieval day. Method of measurement: embryology results.;Achieved and transferred embryos number and quality. Timepoint: 48-72 hours after oocyte retrieval. Method of measurement: embryology results.;Chemical pregnancy rate. Timepoint: day 13 after embryo transfer. Method of measurement: laboratory results.;Clinical pregnancy rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound results.;Implantation rate. Timepoint: 4 weeks after embryo transfer. Method of measurement: Ultrasound results.;Cancellation rate. Timepoint: day 13 after embryo transfer. Method of measurement: patient records. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLadan Mohammadi Yeganeh
Royan institute
Outcome results
None listed