Use of nitrous oxide for laparoscopic cholecystectomy

Comparing physiologic consequences and side effects of N2O and CO2 ?pneumoperitoneum for laparoscopic cholecystectomy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138806092389N1

Enrollment

Registered

2011-04-22

Start date

2010-07-06

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cholelithiasis. Calculus of gallbladder without cholecystitis

Interventions

Intervention 1: Use of nitrous oxide for creating pneumoperitoneum in laparoscopic cholecystectomy. Intervention 2: Use of carbon dioxide for creating pneumoperitoneum in laparoscopic cholecystectomy.

Treatment - Other

Use of nitrous oxide for creating pneumoperitoneum in laparoscopic cholecystectomy.

Use of carbon dioxide for creating pneumoperitoneum in laparoscopic cholecystectomy.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: inclusion criteria:cholelithiasis, suitable for laparoscopic cholecystectomy, informed consent, ASA Score=1&2 exclusion criteria: complicated cholelithiasis including cholecystitis and suppurative cholangitis, complete inability to move, mental disorder percluding communication, pregnancy, known cancer case

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Heart rate. Timepoint: before and during pneumoperitoneum. Method of measurement: beat per minute with anasthesia monitoring devices.;Mean arterial pressure. Timepoint: before and during pneumoperitoneum. Method of measurement: mmHg as detected by anasthetic monitoring devices.;End tidal CO2. Timepoint: before and during pneumoperitoneum. Method of measurement: mmHg as detected by anasthetic monitoring devices.;Minute ventilation. Timepoint: before and during pneumoperitoneum. Method of measurement: product of tidal volume and respiratory rate as controlled by anasthetic devices.;Arterial oxygen saturation. Timepoint: before and during pneumoperitoneum. Method of measurement: percent as detected by anasthetic monitoring devices.;Intraoperative complications. Timepoint: from instillation of gas till complete recovery. Method of measurement: as diagnosed by surgeon and anasthesiologist.;Postoperative complications. Timepoint: from transfer of the patient to ward till discharge. Method of measurement: as diagnosed by surgeon and anasthesiologist.;Pain. Timepoint: 2, 6 and 24 hour post-operation. Method of measurement: visual analogue scale.;Shoulder pain. Timepoint: every time before discharge. Method of measurement: as declared by patient upon questioning.;Vomiting. Timepoint: every time before discharge. Method of measurement: as declared by patient upon questioning.;Analgesics administered post-oparatively. Timepoint: during admission of the patient. Method of measurement: mg/kg as documented by nurse.;Antiemetics administered postoperatively. Timepoint: during admission of the patient. Method of measurement: mg/kg as documented by nurse.;Ability to move in bed. Timepoint: 6 hour post-operatively. Method of measurement: as assessed by researcher.;Ability to move out of bed. Timepoint: 6 hour post-operatively. Method of measurement: as assessed by researcher.	—

Measure

Time frame

Heart rate. Timepoint: before and during pneumoperitoneum. Method of measurement: beat per minute with anasthesia monitoring devices.;Mean arterial pressure. Timepoint: before and during pneumoperitoneum. Method of measurement: mmHg as detected by anasthetic monitoring devices.;End tidal CO2. Timepoint: before and during pneumoperitoneum. Method of measurement: mmHg as detected by anasthetic monitoring devices.;Minute ventilation. Timepoint: before and during pneumoperitoneum. Method of measurement: product of tidal volume and respiratory rate as controlled by anasthetic devices.;Arterial oxygen saturation. Timepoint: before and during pneumoperitoneum. Method of measurement: percent as detected by anasthetic monitoring devices.;Intraoperative complications. Timepoint: from instillation of gas till complete recovery. Method of measurement: as diagnosed by surgeon and anasthesiologist.;Postoperative complications. Timepoint: from transfer of the patient to ward till discharge. Method of measurement: as diagnosed by surgeon and anasthesiologist.;Pain. Timepoint: 2, 6 and 24 hour post-operation. Method of measurement: visual analogue scale.;Shoulder pain. Timepoint: every time before discharge. Method of measurement: as declared by patient upon questioning.;Vomiting. Timepoint: every time before discharge. Method of measurement: as declared by patient upon questioning.;Analgesics administered post-oparatively. Timepoint: during admission of the patient. Method of measurement: mg/kg as documented by nurse.;Antiemetics administered postoperatively. Timepoint: during admission of the patient. Method of measurement: mg/kg as documented by nurse.;Ability to move in bed. Timepoint: 6 hour post-operatively. Method of measurement: as assessed by researcher.;Ability to move out of bed. Timepoint: 6 hour post-operatively. Method of measurement: as assessed by researcher.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi, Asgari

Jundi Shapur Medical University

asgarime@ajums.ac.ir+98 61 1333 3050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026