Condition 1: symptomatic gallstones. Condition 2: polyps of gallbladder. Cholelithiasis Other diseases of gallbladder
Conditions
Interventions
Intervention 1: single dose of ceftriaxone, 1 gr. during induction of anesthesia. Intervention 2: single dose of normal saline ,10 cc during induction of anesthesia. Intervention 3: laparoscopic chole
Prevention
Placebo
Treatment - Surgery
single dose of ceftriaxone, 1 gr. during induction of anesthesia
single dose of normal saline ,10 cc during induction of anesthesia
laparoscopic cholecystectomy
Sponsors
Vice-Chancellor for Research,Shahid Beheshti University of Medical Science
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1-aged 20-80, 2- cholelithiasis with acute/chronic cholecystitis [based on three of the following signs; abdominal pain in the upper right quadrant, Murphy’s sign, leucocytosis > 10000/mm³, rectal temperature > 38 °C or < 36.5 °C plus, cholecystolithiasis (stones/sludge) or sonographic signs of cholecystitis (thickening and triple layer formation of the gall bladder wall) or polyps of gallbladder], 3- admitted in Shohada-e-Tajrish Hospital, Tehran, Iran for cholecystectomy between 2006 and 2008. Exclusion criteria: 1- Pregnant women, 2-patients with jaundice at the time of diagnosis, 3- coagulopathy, 4-coledocholithiasis, 5- portal hypertension, 6- diabetes mellitus, 7- immunosuppressive disorders, 8-previous biliary surgery, 9- biliary pancreatitis, 10- history of antibiotic consumption within one week before surgery, 11-allergic reaction/anaphylaxis to penicillin or cephalosporins, 12- any acute emergency interventions, 13- any contraindications for LC (previous history of abdominal surgery), 14 -conversion from LC to OC, 15- do not agree with conditions of study.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complications of surgery method. Timepoint: during and one weak after surgery. Method of measurement: history and physical exam.;Spillage of bile/gallstone. Timepoint: during surgery. Method of measurement: observation.;Need for Subhepatic drain. Timepoint: within one weak after surgery. Method of measurement: cc of secretion.;Mean operation time. Timepoint: period between begining and end of surgery. Method of measurement: minute.;Bile culture results. Timepoint: one week after surgery. Method of measurement: culture results ,colony formation.;Surgical site infection. Timepoint: within one weak after surgery. Method of measurement: history,physical exam.;Hospital Stay. Timepoint: period between admition for surgery and discharge. Method of measurement: days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMohamad Reza Sobhiyeh
Shahid Beheshti University of Medical Sciences
Outcome results
None listed