Lead poisoning. Toxic effects of lead and its compounds
Conditions
Interventions
Intervention 1: Penicillamine Cap 250 mg 4 times daily for 4 weeks. Intervention 2: Garlic Tab 400 mg 4 times daily for 4 weeks (each tablet contains 1200 microgram allicin).
Treatment - Drugs
Penicillamine Cap 250 mg 4 times daily for 4 weeks
Garlic Tab 400 mg 4 times daily for 4 weeks (each tablet contains 1200 microgram allicin)
Sponsors
Research Department, Mashhad University of Medical Sciences
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion criteria: employees who has worked more than one year in a car battery industry, blood lead levels of 200-500 µg/L Exclusion criteria: family history of allergy to penicillin and drugs that have cross-sensitivity to penicillin, antimalarial drugs and gold salt, history of agranolocytosis or anemia in previous use of penicillamine, known heart, liver or renal failure, hypersensitivity to garlic, hemorrhagic diathesis, elective surgery during and 10 days after the consumption of garlic, using antibiotics or anticoagulant drugs
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood lead levels. Timepoint: Baseline and 1 month after the intervention. Method of measurement: by atomic absorption device, model Perkin Elmer 3030, through the technique of Heated Graphite Atomization.;Signs and symptoms. Timepoint: Baseline and 1 month after the intervention. Method of measurement: medical examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects. Timepoint: routine medical examination to find possible abnormal signs and symptoms - Complete blood count 15 days after the initiation of intervention. Method of measurement: Routine medical examination - Complete blood count 15 days after the initation of treatment.;Blood sugar. Timepoint: Baseline and 1 month after the intervention. Method of measurement: laboratory testing.;Liid profile invluding (cholestrol, triglyceride, HDL and LDL). Timepoint: Baseline and one month after the intervention. Method of measurement: laboratory testing. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mahdi Balali Mood
Medical Toxicology Center
Outcome results
None listed