Preeclampsia. Pre-existing hypertension complicating pregnancy, childbirth and the puerperium
Conditions
Interventions
Intervention 1: testing group 1: aspirin (100mg) at awakening, 1 pill per day. Intervention 2: testing group 2: aspirin (100mg) at bed time, 1 pill per day. Intervention 3: control group 1: placebo at
Prevention
testing group 1: aspirin (100mg) at awakening, 1 pill per day
testing group 2: aspirin (100mg) at bed time, 1 pill per day
control group 1: placebo at awakening, 1 pill per day
control group 2: placebo at bed time, 1 pill per day
Sponsors
Deputy for Research of Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
17 Years to 42 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: women with personal and family history of gestational hypertension and preeclampsia, history of spontaneous abortion, obesity, adolescent or middle age nulliporous pregnancy (less than 18 or more than 35 years). Exclusion criteria: using steroidal , non steroidal or antihypertensive drugs, multiple pregnancy, cardiovascular disease, chronic gastroenteritis and adrenal disease, asthma, hemorrhage disease, diabetes or any other endocrine disease ,hyperthyroidism, hematological disease ,intolerance to devise ,Ambulatory blood pressure monitoring.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24 hours mean of blood pressure. Timepoint: 7 times, every month from the day of recruitment. Method of measurement: 24 hour Blood pressure monitoring automatic device. | — |
Secondary
| Measure | Time frame |
|---|---|
| Preeclampsia prevention and decrease fetal and maternal complications. Timepoint: during and at the end of the pregnancy. Method of measurement: clinically and sonography approved by specialist. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed