Teeth with irreversible pulpitis. Diseases of pulp and periapical tissues
Conditions
Interventions
Intervention 1: Ibuprofen, 1 capsule of 600 mg, 1 hour before the local anesthetic injection. Intervention 2: Indomethacin, 1 capsule of 75 mg, 1 hour before the local anesthetic injection. Interventi
Treatment - Drugs
Placebo
Ibuprofen, 1 capsule of 600 mg, 1 hour before the local anesthetic injection
Indomethacin, 1 capsule of 75 mg, 1 hour before the local anesthetic injection
Sponsors
Oral and Dental Resrach Center and Vice-Chancellor for Research, Kerman University of Medical Scienc
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age more than 18 years, no contraindications to taking either Ibuprofen or Indomethacin (history of any allergic reaction to aspirin, NSAIDS, or Lidocaine with Epinephrine, nasal polyp, history of peptic ulcers or GI bleeding, pregnancy and lactation, renal or hepatic disease), no history of GI disorders or ulcer, having no serious systemic disease. Exclusion criteria: no response to cold test, having sensitivity to percussion and palpation, having radiographic changes such as PDL widening, lack of vital pulp in coronal pulp chamber access cavity preparation, teeth with evidence of crack in their crown, having advanced periodontal disease, taking narcotic drugs or analgesic drugs in recent 12 hours before treatment.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to cold test. Timepoint: 1 hour after taking drug. Method of measurement: using cold spray. | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain. Timepoint: After injection of local anesthesia and during treatment. Method of measurement: using visual analoug scale (VAS). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactNozar Nakhaee
Kerman University of Medical Sciences
Outcome results
None listed