Vasovagal syncope. Syncope and collapse
Conditions
Interventions
Intervention 1: Midodrine 5 mg tid if neccessary 10 mg tid for one year. Intervention 2: Placebo 5 mg tid if neccessary 10 mg tid for one year.
Treatment - Drugs
Midodrine 5 mg tid if neccessary 10 mg tid for one year
Placebo 5 mg tid if neccessary 10 mg tid for one year
Sponsors
Research department of Rajaie Cardiovascular Medical and Research Center
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: (1) a frequency of at least one episode of syncope during previous 6-month and (2) a positive head-up tilt test. Exclusion criteria: (1) other causes of syncope; (2) cardiovascular and /or systemic disease; or (3) systolic blood pressure >150 mmHg or diastolic blood pressure >95 mmHg; or (4) thyrotoxicosis; or (5) renal failure; or (6) pheochromocytoma.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syncope recurrence. Timepoint: 6-monthe and one year after treatment. Method of measurement: History. | — |
Secondary
| Measure | Time frame |
|---|---|
| Satisfaction score. Timepoint: 6-month and one year after treatment. Method of measurement: History (score 0=no response, score 6=excellent response).;Quality of life. Timepoint: 6-month and one year after treatment. Method of measurement: Endicott quality of life questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Human Bakhshandeh
Rajaie Cardiovascular Medical and Research Center
Outcome results
None listed