Comparison the effect of Modified Atkins diet in decreasing frequency of seizure in adult patients with refractory epilepsy with using Modified Atkins diet and patients with refractory epilepsy control without using Modified Atkins diet group.

Evaluation the effect of Modified Atkins diet in controlling refractory epilepsy in adult patients and comparing with adult epileptic patients without using this diet: a controlled randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT138803051949N1

Enrollment

Registered

2013-02-09

Start date

2010-01-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

epilepsy. Localization-related (focal)(partial) idiopathic epilepsy and epileptic syndromes with seizures of localized onset

Interventions

Intervention 1: 1- Case group: Modify Atkin's diet (Less than 15 gr carbohydrate/day in diet) for two months. Intervention 2: 2- Control group: No diet.

Lifestyle

1- Case group: Modify Atkin's diet (Less than 15 gr carbohydrate/day in diet) for two months

2- Control group: No diet

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Inclusion Criteria: >18 years; taking at least two types of anticonvulsants; at least have monthly seizures. Exclusion Criteria: Adults with hypercholesterolemi, cardiovascular, renal disease; patients significantly underweight (body mass index < 18.5); status epilepticus within the past 6 months; nonepileptic seizures

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Decrease of 50% number of seizure attack. Timepoint: In the first day and every 4 weeks till two months. Method of measurement: history.	—

Secondary

Measure	Time frame
Increase of ketone body. Timepoint: weekly. Method of measurement: urinary dipstick.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Zare

Isfahan University of Medical Sciences

zare@med.mui.ac.ir+98 31 1625 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026