Condition 1: varicocele. Condition 2: Male infertility. Scrotal varices Male infertility
Conditions
Interventions
Intervention 1: Folic acid Capsules 5 mg/day, orally plus Zinc sulfate 50 mg/day orally for six months. Intervention 2: Zinc sulfate Capsules 50 mg/day, orally plus placebo capsules with the same dose
Treatment - Drugs
Placebo
Folic acid Capsules 5 mg/day, orally plus Zinc sulfate 50 mg/day orally for six months
Zinc sulfate Capsules 50 mg/day, orally plus placebo capsules with the same dose and shape as Folic acid capsules for 6 months
Folic acid Capsules 5 mg/day, orally plus placebo capsules with the same dose and shape as Zinc sulfate capsules for 6 months
Placebo capsules filled with starch with the same dose and shape as active drugs (Folic acid and Zinc sulfate capsules) for 6 months
Sponsors
Kerman University of Medical Sciences
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion criteria: Men with a history of varicocele. Exclusion criteria: Men with a history of cancer of testis, high blood pressure (systolic blood pressure >140 mmHg), or diabetes.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in sex hormone. Timepoint: Before intervention, 3 mo, and 6 mo after intervention. Method of measurement: Evaluation of hormones by ELIZA.;Quality of semen. Timepoint: Before intervention, 3 mo, and 6 mo after intervention. Method of measurement: sperm analysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in fertility status. Timepoint: 1 y. Method of measurement: Rise in hCG/ sonographic evaluation. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Noureddin Nematollahi-mahani
Kerman University of Medical Sciences
Outcome results
None listed