Condition 1: Common migraine. Condition 2: Classical migraine. Migraine without aura [common migraine] Migraine with aura [classical migraine]
Conditions
Interventions
Intervention 1: Topiramate tablet 25 mg twice a day orally, for 12 months. Intervention 2: Sodium valporate tablets 200mg twice a day orally, for 12 months.
Treatment - Drugs
Topiramate tablet 25 mg twice a day orally, for 12 months
Sodium valporate tablets 200mg twice a day orally, for 12 months
Sponsors
Vice-chancellor for research, Kermanshah University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: more than 4 and less than 10 attacks monthly, patient age at onset of headache less than 50 years, patient’s age between 18-65 years, discontinuation of other prophylactic drugs one month prior to study, interval between attacks more than 48 hours Exclusion criteria: pregnancy and breast feeding, non-migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of headache. Timepoint: in each migraine attack. Method of measurement: patient will record the headache severity in daily notes as VAS (from 1 to 10) & physician registers them every 4 weeks.;Duration of migraine attack. Timepoint: in each migraine attack. Method of measurement: patient records the hours of headache in each attack , physician register them every 4 weeks.;Headache frequency. Timepoint: every 4 week. Method of measurement: According to patients daily notes.;Analgesic use. Timepoint: every 4 week. Method of measurement: According to patients daily notes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical side effects. Timepoint: every 4 weeks. Method of measurement: According to patients daily notes.;Blood cell count & liver function test changes. Timepoint: before and at the end of treatment course. Method of measurement: lab tests. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Dariush Afshari
Farabi hospital
Outcome results
None listed