Rheumatoid arthritis. Other seropositive rheumatoid arthritis
Conditions
Interventions
Intervention 1: First group: Cabergoline (1mgr/week) for 3 months and after one month as wash out period, we will change drug to placebo. Intervention 2: Second group: Placebo (once weekly) for 3 mon
Treatment - Drugs
First group: Cabergoline (1mgr/week) for 3 months and after one month as wash out period, we will change drug to placebo
Second group: Placebo (once weekly) for 3 months and after one month as wash out period, we will change placebo to cabergoline (1mgr/week)
Sponsors
Mazandaran University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: patient with Rheumatoid Arthritis (RA) based on ACR (american college of romahthology) 1987 criteria and activity of RA will be defined as existence of 4 swollen joints and two of these : 6 tender joints, morning stiffness>30 minutes and ESR=28. Patients should be received DMARDs (diseases modifying slow acting anti rheumatiod drugs) at least for 3-6 months before entry to study. Exclusion criteria includes: patient uncompromised, psychological problems, pregnancy and lactation.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of tender joints. Timepoint: before prevention and 3,4 and 7 month after prevention. Method of measurement: taking history and Questionnaire.;Morning stiffness. Timepoint: before prevention and 3,4 and 7 month after prevention. Method of measurement: taking history and Questionnaire.;The number of swollen joints. Timepoint: before prevention and 3,4 and 7 month after prevention. Method of measurement: examination.;Pain. Timepoint: before prevention and 3,4 and 7 month after prevention. Method of measurement: VAS. | — |
Secondary
| Measure | Time frame |
|---|---|
| ESR. Timepoint: before intervention and 3,4 and 7 mounth after treatment. Method of measurement: labratory.;Prolactine. Timepoint: before intervention and 3,4 and 7 mounth after treatment. Method of measurement: labratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMotahareh Kheradmand
Mazandaran Univercity of medical sciences and Health ervices
Outcome results
None listed