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Clinical and Microbiological Effects of 2/5% Acyclovir Gel

The Effects of Subgingival Use of 2/5% Acyclovir Gel on Clinical and Microbiological parameters in Chronic periodontitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT138801231809N1
Enrollment
18
Registered
2009-07-25
Start date
2008-04-05
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic periodontitis. Chronic periodontitis

Interventions

Intervention 1: Intervention group: Supra and Subgingival scaling and rootplaning (hand & ultrasonic instrumentents)+2.5% subgingival acyclovir gel (by an end cut syringe which was put in pocket). Int
Treatment - Drugs
Treatment - Other
Intervention group: Supra and Subgingival scaling and rootplaning (hand & ultrasonic instrumentents)+2.5% subgingival acyclovir gel (by an end cut syringe which was put in pocket)
Control group: Supra and Subgingival scaling and root planing (hand & ultrasonic instrumentents)

Sponsors

Dental School, Shiraz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Inclusion criteria: Presence of chronic periodontitis, presence of at least 2 pockets with 5 mm pocket depth Exclusion criteria: Presence of any systemic disease, periodontal treatment during 6 month prior to study, antibiotic use during 3 months prior to study, Smoking, Pregnancy, or breast feeding

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
P. Gingivalis Count. Timepoint: Baseline (Before Treatment), 1 & 3 months after treatment. Method of measurement: Mycrobiological Analysis ( Culture & PCR).;Clinical Attachment Level. Timepoint: Baseline (Before Treatment), 1 & 3 month after treatment. Method of measurement: Clinical Evaluations.;Pocket Depth. Timepoint: Baseline (Before Treatment), 1 & 3 months after treatment. Method of measurement: Clinical Evaluations (Probing).;Gingival Index. Timepoint: Baseline (Before Treatment), 1 & 3 month after treatment. Method of measurement: Clinical Evaluations.;Bleeding On Probing. Timepoint: Baseline (Before Treatment), 1 & 3 month after treatment. Method of measurement: Clinical Evaluations.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Kobra vasegh
vaseghk@sums.ac.ir+98 21 8877 3550

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026