Rheumatoid arthritis. Seropositive rheumatoid arthritis
Conditions
Interventions
Infusion of 60 mg Pamidronate intravenously each month for three months.
Treatment - Drugs
Infusion of 60 mg Pamidronate intravenously each month for three months
Sponsors
Vice chancellery of research
Eligibility
Sex/Gender
All
Age
16 Years to 100 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Rheumatoid arthritis patients who don’t have enough clinical and laboratory response to conventional disease modifying anti rheumatic drugs (DMARDs). Exclusion criteria: patients who don’t want to have injection or had drug allergy or hypersensitivity, Drug reaction in the course of injection or after that, Lapse from study, Immigration or death.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease activity. Timepoint: Before of injection, every month until 3 months, then 6 months after first injection. Method of measurement: DAS28. | — |
Secondary
| Measure | Time frame |
|---|---|
| Anti inflammatory effect of pamidronate. Timepoint: Before of injection, every month until 3 months, then 6 months after first injection. Method of measurement: DAS28, ESR, VAS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMansour Salesi
Isfahan University of Medical Sciences
Outcome results
None listed