Condition 1: post operative pain. Condition 2: Skeletal muscle relaxants. Myalgia Skeletal muscle relaxants [neuromuscular blocking agents]
Conditions
Interventions
Intervention 1: Remifentanil: in remifentanil group induction regimen is as follow: At time 0, injection of fentanyl 1 µg/kg and pretreatment (remifentanil 1µg/kg that be adjusted to a 3-mL volume) 2
Treatment - Drugs
Placebo
Remifentanil: in remifentanil group induction regimen is as follow: At time 0, injection of fentanyl 1 µg/kg and pretreatment (remifentanil 1µg/kg that be adjusted to a 3-mL volume) 2 min later, then
0.9 saline normal: In saline group induction regimen is as follow: At time 0, injection of fentanyl 1 µg/kg and pretreatment ( 3 ML 0.9 saline normal) 2 min later, then propofol 2 mg/kg and after loss
Sponsors
Kurdistan university of medical siences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: American Society of Anesthesiologists (ASA) physical status I or II, ambulatory urological or gynecological surgery under general anesthesia. Exclusion criteria : arrhythmia, hypo- or hypertension, hyperkalemia, increased intraocular pressure, increased intracranial pressure, presenting a difficult airway, pregnant, treatment with any drug known to interact with neuromuscular function, and significant renal, neuromuscular, or hepatic disease.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle fasciculation. Timepoint: after adminstration of succinylcoline. Method of measurement: Observational by 4-point scale: no fasciculation= 0; mild, fine fasciculation of the eyes, neck, face or fingers without limb movement = 1; moderate fasciculation occurring at more than two sites or obvious limb movement = 2; vigorous or severe, sustained, and widespread fasciculation = 3.;Post operative pain. Timepoint: 1 ,6 and 24 hours after operation. Method of measurement: 4-point scale: nil = no muscle pains or stiffness; mild = muscle pains or stiffness at one site but not causing disability or limiting activities; moderate = muscle pains or stiffness at more than one site but not causing disability or limiting activities; severe = muscle pains or stiffness at one site or more and causing disability or limiting activities, e.g., difficulty getting out of bed or turning the head. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure changes. Timepoint: before induction of anesthesia and after ending fasciculation. Method of measurement: automated oscilometer.;Heart rate changes. Timepoint: Before induction of anesthesia and after ending fasciculation. Method of measurement: BSI (passport2) automated monitor. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMehdi Tayebi Arasteh
Faculty of medicine
Outcome results
None listed