Clomiphene citrate vs letrozole in patients undergoing intra uterine semen injection

Comparison of the efficacy of clomiphene citrate and letrozole in patients undergoing intra uterine semen injection on the pregnancy rate.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138712141744N1

Enrollment

160

Registered

2011-10-03

Start date

2008-12-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility. Female infertility

Interventions

Intervention 1: Control group ( Clomiphene Citrate) : Clomiphene Citrate 100 mg was given for 5 days starting from day 3 of menstrual cycle. In addition, human menopausal gonadotropin (hMG) 150 IU wa

Treatment - Drugs

Control group ( Clomiphene Citrate) : Clomiphene Citrate 100 mg was given for 5 days starting from day 3 of menstrual cycle. In addition, human menopausal gonadotropin (hMG) 150 IU was administered

Intervention group ( Letrozole ) : 5 mg Letrozole for 5 days from day 3 to 7 of menstrual cycle. In addition, human menopausal gonadotropin (hMG) 150 IU was administered every day, starting on

Eligibility

Sex/Gender

Female

Age

15 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: patients candidate of IUI( ovulatory factor; male factor infertility; patients with cervical factor; endometriosis and idiopathic infertility); Normal Pelvic USG and bilateral tubal patency. Exclusion Criteria: Age more than 35; FSH more than 10 on day 3 of menstruation cycle; Uterine and adnexal pathology e.g. leiomyoma; Ovarian cyst on USG., Impaired hepatic /renal function; Diabetes mellitus; History of hypersensitivity to the study drug or to its excipients; Bilateral tubal obstruction on HSG

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pregnancy rate. Timepoint: 14 days after intra uterine insemination. Method of measurement: Blood test for assay of BHCG.;Abortion rate. Timepoint: From positive test of BHCG to 20th weeks of gestation. Method of measurement: Pregnancy loss before 20th weeks of gestation determined with ultrasunogeraphy.	—

Secondary

Measure	Time frame
Endometrial thickness. Timepoint: In the time of HCG injection. Method of measurement: Transvaginal ultrasonogeraphy.;Number of follicles. Timepoint: In the time of HCG injection. Method of measurement: Transvaginal ultrasonograghy.;Serum estradiol level. Timepoint: In the time of hCG injection. Method of measurement: Blood test(microgram/dl).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAyazi Roozbahani Maryam

Erfan Hospital

ayaziroz@gmail.com+98 21 2235 9153

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026