Burn wound treatment. Burns and corrosions
Conditions
Interventions
Intervention 1: The intervention group: Propranolol orally with the dose of 1mg/kg/day and maximum dose of 1.98 mg/kg/day given in 6 divided doses. Intervention 2: The control group: Placebo, similar
Treatment - Drugs
The intervention group: Propranolol orally with the dose of 1mg/kg/day and maximum dose of 1.98 mg/kg/day given in 6 divided doses.
The control group: Placebo, similar to active drug with the same dose
Sponsors
Vice-chancellorship for Research, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Burn size 20% to 50% of the total body surface area (TBSA) Exclusion criteria: Presence of cardiac or endocrine diseases, peripheral vascular disease, history of asthma, systolic blood pressure<90 and heart rate<60 after primary resuscitation, and inhalation injury.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Wound healing time. Timepoint: daily. Method of measurement: time between admission and epithelialization or preparation for skin graft.;Surface area of wounds needed to be grafted. Timepoint: daily. Method of measurement: by specific ruller.;Level of hemoglobin. Timepoint: twice a week. Method of measurement: cell counter (sysmeex).;Serum albumin level. Timepoint: twice a week. Method of measurement: check serum albumin level by BCG method (Bromocresol green). | — |
Secondary
| Measure | Time frame |
|---|---|
| Hospital stay period. Timepoint: daily. Method of measurement: time of admission in the hospitals in days. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Akbar Mohammadi
Shiraz University of Medical Sciences
Outcome results
None listed