Safety and usefulness of Enoxaparin versus unfractionated heparin in patients with ST elevation myocardial infarction

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT138711271695N1

Enrollment

150

Registered

2009-04-25

Start date

2006-06-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischaemic heart diseases. Acute myocardial infarction

Interventions

Intervention 1: Streptokinase (1.5 million units intravenously over 1 h) plus unfractionated heparin for a minimum of 48 hours and adjusted to the activated partial thromboplastin time according to th

Treatment - Drugs

Streptokinase (1.5 million units intravenously over 1 h) plus unfractionated heparin for a minimum of 48 hours and adjusted to the activated partial thromboplastin time according to the American Heart

Streptokinase (1.5 million units intravenously over 1 h) plus Enoxaparin was administered as an intravenous bolus (40 mg) and then subcutaneously every 12 hrs (1 mg/kg) with a maximum of 100 mg for th

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria: Age range 18 to 75 years old, onset of symptoms of acute myocardial infarction within 12 hrs before randomization, ST-segment elevation of 0.1 mV or more in two or more limbs leads or at least 0.2 mV in two or more precordial leads. Exclusion Criteria: Contraindications to streptokinase, cardiogenic shock, receiving glycoprotein IIb/IIIa antagonists or oral anticoagulants within the prior days or therapeutic dose of heparin or low molecular-weight heparin within the previous hours, need for anticoagulant therapy and also any other disease that resulted in increasing risk

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
ST-segment resolution. Timepoint: 90 minutes after intervention. Method of measurement: ECG.;Ejection Fraction. Timepoint: during 5-10th day of admission. Method of measurement: Angiography.;Thombolysis in Myocardial Infarction (TIMI) flow grade 3 (patency). Timepoint: during 5-10th day of admission. Method of measurement: Through angiography.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Reza Pourbehi

Bushehr University of Medical Sciences and Health Services

m_purbehi@yahoo.com+98 77 1252 4044

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026