Atrial fibrillation. Atrial fibrillation and flutter
Conditions
Interventions
Intervention 1: Patients in case group will receive atorvastatin 20 mg, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiratio
Prevention
Placebo
Patients in case group will receive atorvastatin 20 mg, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator,
Patients in control group will receive placebo, once daily 3 days before surgery, and 6 hours after extubation up to the day 5 after surgery. In the case of assisted respiration by ventilator, the dru
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients undergoing isolated coronary artery bypass graft surgery. Exclusion criteria: 1. History of atrial fibrillation; 2. Renal failure with plasma creatinine greater than 2 mg/dl; 3. Malignant or inflammatory diseases; 4. Routine use of atorvastatin; 5. Mixed cardiac operations including valve replacement; 6. Using antiarrhythmic drugs except beta-blockers; 7. Active hepatic-biliary diseases; 8. Increase in serum transaminases with undetermined cause; 9. Patients re-operated because of bleeding or other complications of surgery; 10. Glucocorticoids use.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Atrial fibrillation after Coronary Artery Bypass Graft surgery. Timepoint: During 5 days after operation. Method of measurement: ECG monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHossein Mirkhani
Shiraz University of Medical Sciences
Outcome results
None listed