Mild to moderate Alzheimer. Dementia in Alzheimer's disease
Conditions
Interventions
Intervention 1: Intervention: Capsule of Saffron 30 mg/day. Intervention 2: Control: Tab Donepezil 10 mg/day.
Treatment - Drugs
Intervention: Capsule of Saffron 30 mg/day
Control: Tab Donepezil 10 mg/day
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: A diagnosis of probable Alzheimer’s disease according to the criteria of National Institute of Neurological and Communicative Disorders and Stroke and Alzheimer’s Disease and Related Disorders Association (NINCDS/ADRDA); Presence of mild to moderate dementia [score of = 12 on the cognitive subscale of Alzheimer’s Disease Assessment Scale (ADAS-cog) and = 2 on Clinical Dementia Rating Scale (CDR)]. Exclusion Criteria: Concomitant diseases such as hypertension, congestive heart failure, non-insulin dependent diabetes mellitus and hypothyroidism; Patients with evidence of other neurodegenerative disorders; Any cardiovascular disease likely to prevent completion of the study; Clinically significant psychiatric diseases; Urinary outflow obstruction; Active peptic ulcer; Any history of epilepsy; Significant drug or alcohol misuse; Drugs with anticholinergic effects or cholinomimetic effects.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of Alzheimer. Timepoint: Every month. Method of measurement: ADAS-cog. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of Alzheimer. Timepoint: Every Month. Method of measurement: CDR-SB. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed